Csf2ra macrophage

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August undefined, 2024

WebCSF2RA (alphaGMR, CD116, CSF2R) protein expression summary. The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a c ytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. WebOriginal Article Long-Term Safety and Efﬁcacy of Gene-Pulmonary Macrophage Transplantation Therapy of PAP in Csf2ra / Mice Paritha Arumugam, 1,2Takuji Suzuki, 6 Kenjiro Shima, 1,2Cormac McCarthy, Anthony Sallese, Matthew Wessendarp, 1,2Yan Ma, Johann Meyer,5 Diane Black,1,2 Claudia Chalk, Brenna Carey, Nico Lachmann, …

CSF2RA protein expression summary - The Human Protein Atlas

WebHuman Gene CSF2RA (uc004cpp.2) Description: Homo sapiens colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (CSF2RA), transcript variant 3, mRNA. RefSeq Summary (NM_172246): WebOct 18, 2024 · Klemm et al. show that resistance to CSF1R inhibition in breast cancer brain metastasis is driven by compensatory activation of the CSF2Rb–STAT5 axis in macrophages, which can be alleviated by ... dapper browser

CSF2RA Antibodies

WebHuman Gene CSF2RA (uc010ncu.2) Description: Homo sapiens colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (CSF2RA), transcript variant 11, non-coding RNA. WebCSF2RA. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 400. Protein existence. Evidence at protein level. ... Function. function. Low … WebNov 1, 2024 · This network analysis identified a less well-known gene, colony-stimulating factor 2 receptor alpha subunit (CSF2RA), which encodes the alpha chain of the macrophagic receptor for the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) 9, 10, 11 Our follow-up analysis revealed that CSF2RA expression is … birth injury attorney nick oberheiden

From macrophage biology to macrophage-based cellular ... - Nature

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WebNov 26, 2014 · The CSF2RA gene is located in the pseudoautosomal region (PAR) of the X and Y-chromosomes. Information on the chronic lung disease which develops in consequence of CSF2RA mutations is important for the management and prognosis of affected patients, but unfortunately rather scarce. Introduction. Tissue-resident macrophages comprise a variety of heterogeneous, … birth injury attorney mobileWebJul 1, 2024 · Alveolar macrophages derived from fetal monocytes (FeMo-AM) are crucial for defense against respiratory viral infections. During influenza A virus (IAV) infection, FeMo-AM are depleted, but it is unclear whether this population is replenished by self-renewing FeMo-AM or by infiltration of bone marrow–derived (BMo)–AM. dapper bros cleaners

"WebUsing Csf2rb-null mice, which develop a myeloid cell disorder identical to hereditary pulmonary alveolar proteinosis (HPAP/SMDP) in children with CSF2RA or CSF2RB mutations, Suzuki et al. (2014) showed that pulmonary macrophage transplantation (PMT) of either wildtype or Csf2rb gene-corrected macrophages without myeloablation was … " - Csf2ra macrophage

Csf2ra macrophage

Gene therapy of Csf2ra deficiency in mouse fetal monocyte ... - PubMed

WebJul 28, 2016 · By separating the mutations, we established unique Csf2ra-/- mouse model that allows study the role of cell intrinsic GM-CSF receptor signaling in vivo without confounding variables introduced by defective IL-5 receptor and IL-3 receptor signaling in mice lacking the common β chain (Csf2rb). WebThe granulocyte-macrophage colony-stimulating factor receptor also known as CD116 ( C luster of D ifferentiation 116 ), is a receptor for granulocyte-macrophage colony …

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WebApr 4, 2024 · CSF2-cFLiMo–derived alveolar macrophages resemble bona fide alveolar macrophages in gene expression profile, surface markers, and functional capacities, including potent self-renewal capacity, clearance of surfactant, and efferocytosis of apoptotic cells during influenza virus infection. WebNov 2, 2024 · Macrophages from Csf2ra-/- mice were unable to bind and clear GM-CSF, did not exhibit GM-CSF signaling, and had functional defects in phagocytosis, cholesterol clearance, and surfactant clearance.

WebMar 21, 2024 · CSF2RA (Colony Stimulating Factor 2 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with CSF2RA include Surfactant Metabolism … WebCsf2ra : colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) Csf2ra : granulocyte-macrophage colony stimulating receptor alpha : Nomenclature …

WebCSF2RA, “Colony stimulating factor 2 receptor alpha subunit (CD116)”, is a re-ceptor for GM-CSF (granulocyte-macrophage colony-stimulating factor), and plays a vital role for proliferation, differentiation and functional activation of hematopoietic cells such as macrophages and leukocytes . The absence of [1] WebDescription: Homo sapiens colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (CSF2RA), transcript variant 8, mRNA. RefSeq Summary (NM_001161530): The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the …

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WebApr 8, 2024 · CSF2-cFLiMo–derived alveolar macrophages resemble bona fide alveolar macrophages in gene expression profile, surface markers, and functional capacities, including potent self-renewal capacity, clearance of surfactant, and efferocytosis of apoptotic cells during influenza virus infection. dapper chap meaningWebView mouse Csf2ra Chr19:61212395-61216867 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression. Home; ... Mice homozygous for a null allele exhibit pulmonary alveolar proteinosis due to defects in macrophage clearance and abnormal bronchoalveolar fluid containing amorphous debris, peribronciolar … dapper cadaver tf2WebDescription: Homo sapiens colony stimulating factor 2 receptor subunit alpha (CSF2RA), transcript variant 7, mRNA. (from RefSeq NM_001161529) RefSeq Summary (NM_001161529): The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the … birth injury attorney salemWebFeb 4, 2024 · From macrophage biology to macrophage-based cellular immunotherapies. As far back as 1882, Ilya (Elie) Metchnikoff was the first to discover macrophages (MΦ) and their important role in host ... birth injury attorney portlandWebCSF2R was the first gene of known function to be mapped to the PAR, which encompasses about 2,500 kb. Loss of either the X or the Y chromosome is apparent in 25% of acute myeloid leukemias of the M2 subtype (AML-M2), compared with only 1 to 6% of other AML subtypes, suggesting the involvement of a 'recessive oncogene' in the genesis of M2 AMLs. birth injury attorney sherman oaksWebAug 18, 2009 · Using an expression cloning strategy, Gearing et al. (1989) isolated a cDNA encoding CSF2RA, which they called GMCSFR, from a human placenta cDNA library. … birth injury attorney plymouthWebOriginal Article Long-Term Safety and Efﬁcacy of Gene-Pulmonary Macrophage Transplantation Therapy of PAP in Csf2ra / Mice Paritha Arumugam, 1,2Takuji Suzuki, 6 … dapper change tracking