Ctgf in diabetic nephropathy
WebMar 16, 2024 · Microalbuminuria is a hallmark of early stage diabetic nephropathy and usually indicates damage to the glomerular filtration barrier due to ultrastructural changes in podocytes and glomerular endothelial cells rather than alterations in glomerular pressure or filtration rate alone. ... and profibrotic markers (Collagen I and CTGF) DM-N Nakamura ...
Ctgf in diabetic nephropathy
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WebConnective tissue growth factor (CTGF; CCN2) plays a role in the development of diabetic nephropathy (DN). Urinary CTGF (uCTGF) is elevated in DN patients and has been … WebFeb 2, 2008 · CTGF was first identified as a potential player in the molecular network of the diabetic glomerulus, when it was shown by subtractive hybridization that its expression was upregulated in mesangial cells exposed to high glucose.3 Furthermore, CTGF expression was upregulated in podocytes and mesangial cells in several animal models of diabetic …
WebJun 1, 2008 · CTGF is a secreted protein and can be detected in biological fluids. Previous small studies have reported that both urinary CTGF excretion and plasma CTGF levels … WebDiabetic nephropathy (DN) is the most common microvascular complication, which is expected to affect approximately 40–60% of diabetic individuals [5]. DN, also known as Diabetic Kidney Disease (DKD), is the deprivation of kidney function in patients with type 1 and type 2 diabetes [6]. In the absence of other renal disorders, DN is ...
WebDespite substantial progress in medical care, the morbidity rate of diabetic nephropathy (DN) remains high in patients with diabetes. Evidence suggests that connective tissue … WebMar 27, 2024 · The diabetic chronic kidney disease (CKD) model in this study utilized uninephrectomy, high fat diet and one dose of streptozotocin which closely simulates human type 2 diabetic nephropathy. 25, 26 Male Sprague–Dawley rats (body weight 225–250 g, Charles River) were subjected to right nephrectomy under inhaled isoflurane anesthesia.
WebSep 23, 2024 · CTGF, a downstream molecule of TGF-β/Smad, is a novel profibrotic factor that is up-regulated in the glomerulosclerosis of DN. Recent studies have identified that CTGF promotes the abnormal deposition of ECM and fibrosis and thus could enhance the disassembly and hypertrophy of mesangial cells [ 17 ].
WebOct 1, 2001 · Immunohistochemistry detected CTGF protein in glomeruli of kidneys of non-obese diabetic mice 14 days after the onset of diabetes, and this was prominent by 70 days. CTGF protein is also present in glomeruli of human patients with diabetic nephropathy. No CTGF was detected in either normal murine or human glomeruli. how to say teacher in hindiWebJun 1, 2008 · Recently, CTGF has emerged as an important factor in diabetic nephropathy. In renal cells, CTGF is induced by high glucose, and it is critically involved in diabetes-associated changes such as extracellular matrix synthesis, cell migration, and epithelial-to-mesenchymal transition ( 5 – 8 ). how to say teacher in greekWebObjective: Levels of connective tissue growth factor (CTGF; CCN-2) in plasma are increased in various fibrotic disorders, including diabetic nephropathy. Recently, several articles … northlands mental health team sheffieldWebConnective tissue growth factor (CTGF) is overexpressed in diabetic nephropathy (DN) and has therefore been implicated in its pathogenesis. The objective of the present study … how to say teacher in arabicWebCTGF是一个相对分子质量36 000~38 000的细胞蛋白，在TGF-β介导的生物活动中，CTGF参与了组织纤维化的过程。 在DKD患者中，血浆和尿中CTGF的水平增高，尿CTGF增加与UAER增加以及GFR下降有关 [ 14] 。 另一项318例T1DM和29名正常对照的横断面研究也发现，DKD患者中尿CTGF与UAER和GFR相关 [ 15] 。 因此，尿CTGF被认为 … northland smiles dentalWebOct 5, 2024 · Kidney fibrosis is the main pathologic change in diabetic nephropathy (DN), which is the major cause of end-stage renal disease. ... Abbreviations: CTGF, connective tissue growth factor; DM, diabetic model; IHC, immunohistochemistry; PASM, periodic … northlands medical clinic whistler hoursWebConnective tissue growth factor (CTGF; CCN2) plays a role in the development of diabetic nephropathy (DN). Urinary CTGF (uCTGF) is elevated in DN patients and has been … how to say teacher in german