WebOct 14, 1999 · GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M (ref. 3).
Granulocyte Colony Stimulating Factor - an overview - ScienceDirect
Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Functionally, it is a cytokine and hormone, a type of colony … See more G-CSF is produced by endothelium, macrophages, and a number of other immune cells. The natural human glycoprotein exists in two forms, a 174- and 177-amino-acid-long protein of molecular weight … See more The gene for G-CSF is located on chromosome 17, locus q11.2-q12. Nagata et al. found that the GCSF gene has 4 introns, and that 2 different polypeptides are synthesized … See more The skin disease Sweet's syndrome is a known side effect of using this drug. See more The recombinant human G-CSF (rhG-CSF) synthesised in an E. coli expression system is called filgrastim. The structure of filgrastim differs slightly from the structure of the natural … See more Chemotherapy-induced neutropenia Chemotherapy can cause myelosuppression and unacceptably low levels of white blood cells (leukopenia), making patients susceptible to infections and sepsis. G-CSF stimulates the production of See more Mouse granulocyte-colony stimulating factor (G-CSF) was first recognised and purified in Walter and Eliza Hall Institute, Australia in … See more • PEGylation See more WebG-CSF (Neupogen or Filgrastim), granulocyte-colony stimulating factor, is a glycoprotein that has multiple functions in both physiological and pathophysiological conditions. G-CSF stimulates the BM to produce granulocytes and stem cells and release them into the bloodstream. G-CSF also stimulates the survival, proliferation, differentiation ... rohrmotor chamberlain
Hypercalcemia–leukocytosis syndrome from non-schistosomiasis …
WebUnlike granulocyte colony-stimulating factor, which specifically promotes neutrophil proliferation and maturation, GM-CSF affects more cell types, especially macrophages … WebApr 1, 2015 · The protein hormone granulocyte colony-stimulating factor (GCSF) stimulates the production of white blood cells and plays an important role in medical treatment of cancer patients. An efficient ... WebOct 6, 2024 · Granulocyte-colony stimulating factor (G-CSF) is a hormone that causes neutrophils to grow in your bone marrow. The active drug in Neulasta, pegfilgrastim, is a man-made copy of the G-CSF hormone ... rohrmoser andreas