WebSimilarly, Goldenticket mice – which harbor a single nucleotide polymorphism in Sting1 (T596A) that mimics the effects of a loss-of-function mutation – cannot establish efficient IFN-dependent immune responses against Listeria monocytogenes.81,82 Subsequent works, however, sug- gested that STING signaling in neoplastic cells, responding to ... WebNov 22, 2010 · Here we describe a novel mutant mouse strain, Goldenticket (Gt), that fails to produce type I IFNs upon L. monocytogenes infection. By genetic mapping and …
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WebApr 15, 2015 · Palpable B16 tumors were treated in wild-type (WT) and goldenticket (STING −/−) mice. The animals were treated with STINGVAX (20 μg of CDA), and the … WebNov 25, 2024 · In 2011 a STING-deficient “Goldenticket” (Gt) mouse strain was generated by N-ethyl-N-nitrosourea (ENU) mutagenesis where a T596A (I199N) mutation was … imo phone hard reset
The N-Ethyl-N-Nitrosourea-Induced Goldenticket Mouse …
WebSep 5, 2024 · Sting deficiency or Goldenticket mice (Sting gt), which behave as a functional knockout of STING (Sauer et al., 2011). Furthermore, we detected the increase of cGAMP in the splenocytes of the Fcgr2b −/−.Sting wt/gt mice but not in the double-deficient mice (Figure 1 I). WebBMDMs were isolated from WT, STING N153S (SAVI), or STING Goldenticket mice following stimulation with cyclic di-GMP or control. (A and B) Gene expression levels of IFIT1 and ISG15 were measured ... Web025805 B6(Cg)- Sting1 tm1.2Camb /J MPYS -/- (STING KO) mice may be useful for studying cytosolic detection of pathogen DNA, the innate immune response and … listorphil medication