Web6 de jan. de 2024 · Our enrichment analyses showed that after such oxidative stresses, some signaling pathways such as the HIF1-α signaling pathway are activated that can lead to ferroptosis or cell apoptosis through inducing free radicals’ generation after pulmonary fibrosis (Epstein Shochet et al., 2024). Web1 de jan. de 2024 · Recently, ferroptosis-related genes were found obviously changing in spinal cord tissue of SCI (Ge et al., 2024, Yao et al., 2024, Zhou et al., 2024). Ferroptosis is a type of cell death differing from apoptosis, characterized by iron-dependent accretion of lipid peroxidation (Dixon et al., 2012).
Wild-type and mutant p53 in cancer-related ferroptosis. A matter …
Web13 de jan. de 2024 · Ferroptosis is a regulated cell death nexus linking metabolism, redox biology and diseases including cancer. The aim of the present study was to identify a ferroptosis-related gene prognostic signature for stomach adenocarcinoma (STAD) by systematic analysis of transcriptional profiles from The Cancer Genome Atlas (TCGA), … Web31 de mar. de 2024 · Background and Objective: Ferroptosis is a recently discovered form of cell death which differs from other forms of cell death in terms of morphology, biochemistry, and regulatory mechanisms.Ferroptosis is regulated by a complex system and the precise molecular mechanisms are still being elucidated. Over the past few … ray stone apts
Ferroptosis in cancer therapy: a novel approach to reversing drug ...
Web1 de fev. de 2015 · Hypoxia and inflammation are intimately linked. It is known that nuclear factor κB (NF-κB) regulates the hypoxia-inducible factor (HIF) system, but little is known about how HIF regulates NF-κB. Here, we show that HIF-1α represses NF-κB-dependent gene expression. HIF-1α depletion results in increased NF-κB transcriptional activity both … WebMaterials and methods: The effects of sorafenib on HSC ferroptosis and ECM expression were assessed in mouse model of liver fibrosis induced by CCl 4. In vitro, Fer-1 and DFO … Web16 de jun. de 2024 · As the committing event of ferroptosis, PL peroxidation occurs in three steps: initiation, propagation, and termination (Figure 3).The peroxidation of fatty acyl chains of PLs is facilitated by a bisallylic group (–CH=CH–CH 2 –CH=CH–) due to the weak bonds connecting the hydrogens in the central methylene group. These bonds are weak … simply gadgets