High-affinity choline transporter 1

Author: soyk

August undefined, 2024

WebDownload Zoom Anti-Choline Transporter Antibody, high affinity detects level of Choline Transporter & has been published & validated for use in IH & WB. MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. SDS CoA References WebLOC799259 high-affinity choline transporter 1-like [ (zebrafish)] Gene ID: 799259, updated on 4-Nov-2024.

Molecular properties of the high-affinity choline transporter CHT1

Web29 de jul. de 2014 · Highaffinity choline transporter 1 is involved in choline transport from the extracellular space to the neuron (48). Innexin 2 is required for the regulation of neuronal networks (49).... Web22 de jul. de 2024 · The first transporter is high-affinity choline transporter 1 (CHT1) that is expressed in cholinergic neurons and is linked to acetylcholine synthesis, which has a high affinity for choline. The second is organic cationic transporters OCT1 and OCT2 that have low affinity for choline, which recognize many cationic substances, and are mainly … camp bowie family aquatic center

Insulin Regulates the Activity of the High-Affinity Choline Transporter ...

WebThe high-affinity choline transporter (CHT1), which is specifically expressed in cholinergic neurons, constitutes a rate-limiting step for acetylcholine synthesis. We have found that … Web1 de jan. de 2024 · The high-affinity choline transporter was first cloned in 2000 and designated as CHT1 (Okuda et al. 2000 ). Structure and Functional Properties of CHT1 … WebAt high concentrations, choline is transported primarily by a low-affinity and Na + -independent system that is inhibited by hemicholinium-3 (HC3) 10 with a high Ki of … camp bowie craftsman style homes

Blockage of High-Affinity Choline Transporter Increases Visceral ...

Functional characterization of the human high‐affinity choline ...

Web18 de fev. de 2024 · High-affinity choline transporter 1 (CHT1), which is mainly present on the presynaptic terminal and cytoplasm of cholinergic neurons, is involved in the … Web1 de set. de 2016 · HC-3-sensitive choline transport by transfected cells was evaluated on a period of 6 min using 1 μM 14 C-choline (PerkinElmer) subtracting the uptake observed with 1 μM HC-3 (Sigma-Aldrich), since choline uptake by mock-transfected HEK293 cells was not sensitive to this HC-3 concentration. 10 Whole-cell lysates were assayed for … camp bow highland heightsWebThe molecular entity for the high-affinity choline transporter was identified and is designated CHT1, which mediates Na+- and Cl−-dependent choline uptake with high … first steps in a postvention response

"Web5 de mai. de 2024 · To examine the action of tetrahydropyrimidines on the nematode high-affinity choline transporter, we generated HEK293 cell lines stably expressing the high-affinity choline transporter from C. elegans (CHO-1), the ortholog of CHT1 (Okuda et al., 2000), and measured the high-affinity choline uptake activity in the presence of … " - High-affinity choline transporter 1

High-affinity choline transporter 1

(PDF) High-affinity choline transporter T. Haga - Academia.edu

Web1 de mai. de 1990 · It is demonstrated that these two affinity states of [3H]HC‐3 binding are totally interconvertible; addition of 0.1 mM ATP in the binding assay medium quantitatively converted all the binding sites to the low‐affinity state, whereas addition of 1 mM β,γ‐methylene 5′‐ATP quantitatively Conversion of all thebinding sites toThe … Web1 de mai. de 1990 · It is demonstrated that these two affinity states of [3H]HC‐3 binding are totally interconvertible; addition of 0.1 mM ATP in the binding assay medium …

Did you know?

WebProtein target information for High affinity choline transporter 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. Web3 de nov. de 2000 · Na +-dependent, high-affinity choline uptake in cholinergic neurons is the rate-limiting step in acetylcholine synthesis.Here we report the molecular cloning and …

WebComponents. integral component of membrane / neuronal cell body / plasma membrane. General Function. Choline:sodium symporter activity. Specific Function. Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent. Web21 de set. de 2024 · The high-affinity choline transporter CHT1, which is the rate-limiting step for acetylcholine (ACh) synthesis, exerts a crucial role in the functioning of the cholinergic system. 8 CHT1 is present on the presynaptic terminal of cholinergic neurons and can take up choline hydrolyzed from ACh at the synaptic cleft into the presynaptic …

Web18 de jan. de 2010 · The cho-1 gene in Caenorhabditis elegans encodes a high-affinity plasma-membrane choline transporter believed to be rate limiting for acetylcholine (ACh) synthesis in cholinergic nerve terminals. WebIn cholinergic neurons, high-affinity choline uptake in presynaptic terminals is the rate-limiting step in acetylcholine synthesis. Using information provided by the Caenorhabditis …

Web8 de mar. de 2006 · The high-affinity choline transporter at the molecular level. Despite the fact that the high-affinity choline uptake system was described in the 1960s, the …

WebThe high-affinity choline transporter: a critical protein for sustaining cholinergic signaling as revealed in studies of genetically altered mice Authors M H Bazalakova 1 , R D … camp bowie brownwood texasWebThe transporter protein was cloned and identified by Okuda and co-workers in 2000, and shown to exhibit high-affinity, sodium-dependent choline uptake ( Km ~2 μM) which … first steps in counselling pete sandersWebThe High-Affinity Choline Transporter: A Critical Protein for Sustaining Cholinergic Signaling as Revealed in Studies of Genetically Altered Mice M. H. Bazalakova & R. D. Blakely Chapter 1676 Accesses 28 Citations Part of the Handbook of Experimental Pharmacology book series (HEP,volume 175) Abstract camp bow matthews ncWebThe high-affinity choline transporter (CHT1) is responsible for uptake of choline from the synaptic cleft and supplying choline for acetylcholine synthesis. CHT1 internalization by clathrin-coated vesicles is proposed to represent a mechanism by which high-affinity choline uptake can be modulated. camp bowie barber shopWebA choline uptake system with a high affinity for choline has long been assumed to be present in cholinergic neurons. Very recently, the molecular entity for the high-affinity … first steps in counselling pete sanders pdfWebHigh affinity choline transporter 1, Hemicholinium-3-sensitive choline transporter, CHT, Solute carrier family 5 member 7. eCl@ss: 32160702. NACRES: NA.41. Recommended Products. Slide 1 of 10. 1 of 10. Sigma-Aldrich. AV41516. Anti-SLC22A1 (AB1) antibody produced in rabbit. IgG fraction of antiserum. camp bow locationsWebCHT1 protein is mainly found in intracellular organelles, such as endosomal compartments and synaptic vesicles. The presence of CHT1 at the plasma membrane is limited by … first steps in counselling sanders