Nettet1. sep. 2016 · Insulin induced gene-2 (Insig-2) is an ER-resident protein that inhibits the activation of sterol regulatory element-binding proteins (SREBPs). However, …

Anti-INSIG2 Rabbit Polyclonal Antibody VWR

Nettet23. jun. 2008 · Insulin-induced gene insig proteins, including insig-1 and insig-2, play many important roles in regulating cholesterol or TAG synthesis, mainly in the liver. 3-Hydroxy-3-methylglutaryl (HMG)-CoA reductase, a rate-limiting enzyme in cholesterol synthesis, catalyses the reduction of HMG-CoA to mevalonate (1). NettetIncreased levels of glucose uptake and increased expression of the glucose transporter (GLUT) genes are characteristic features of tumors. In the muscle-derived tumor alveolar rhabdomyosarcoma (ARMS), a chromosomal translocation t(2:13) generates the PAX3/forkhead homolog in rhabdomyosarcoma (FKHR) oncoprotein. In muscle tissues, … thief2.exe

Establishing insulin 1 and insulin 2 knockout congenic strains on …

NettetInsulin induced gene 1, also known as INSIG1, is a protein which in humans is encoded by the INSIG1 gene.. INSIG1 is short for insulin-induced gene 1; it is located on … NettetOxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to … NettetDisrupting methyl-CpG-binding protein 2 expression induces the transformation of induced pluripotent stem cell cardiomyocytes into pacemaker-like cells by insulin gene enhancer binding protein 1 Wei Zhang, Wei Zhang Medicine College of Yangzhou University, Yangzhou, Jiangsu, China thief 2 eavesdropping