Web16 jun. 2024 · AD risk variants of MEF2A were significantly enriched both in macrophage and microglia. ... al. (2007) stated that variation in the MEF2A gene could be involved in … WebMechanistically, we showed that MEF2C directly activated the transcription of Il12a and Il12b. These findings reveal a new function of MEF2C in macrophage polarization and …
Frontiers Decreased MEF2A Expression Regulated by Its Enhancer ...
Web22 feb. 2024 · Mef2c is involved in macrophage polarization Macrophages are a heterogeneous population of immune cells that change their phenotype and physiology … Web22 sep. 2011 · Furthermore, results from a functional assay revealed that miR-223 promoted the invasion of breast cancer cells via the Mef2c-β-catenin pathway. Conclusions: We conclude that macrophages regulate the invasiveness of breast cancer cells through exosome-mediated delivery of oncogenic miRNAs. number of chests in inazuma
Frontiers The Role of GPNMB in Inflammation
Web1 feb. 2016 · Macrophage activation is best described by a multi-dimensional model. •. Targeting macrophages specifically requires a multi-modal approach. •. Macrophage reprogramming rather than deletion might be a future therapeutic avenue. •. Transcriptional and epigenetic control might be new drug targets in macrophages. WebChromatin immunoprecipitation assay and dual luciferase assay showed that MEF2C could bind to the MEF2C element in the promoter sequence of MIG6 and promote the transcription of MIG6. This effect increased the gefitinib-resistant ability of cancer cells. WebGene summary (Entrez)i. Useful information about the gene from Entrez. This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of … nintendo switch manual setup