Web20 Nov 2024 · S. Typhimurium has been engineered to deliver immunocompetent cytokines that can induce activation of immune cells and killing of tumor cells. Specifically, S. … WebWe previously showed that two bacterial strains, E. coli K-12 strain (MG1655) and attenuated S. typhimurium defective in the synthesis of ppGpp (ΔppGpp S. typhimurium) have tumor-targeting ability and developed diverse BCT strategies based on these strains [ 9, 13, 14, 16 - …
Genetically engineered Salmonella typhimurium for targeted …
Web21 Jan 2015 · The results of the present study suggest that S. typhimurium A1-R has greater clinical potential than VNP20009, and shows higher tumor targeting and inhibited the … Web11 hours ago · Priming of macrophages with interferon-gamma (IFNγ) or interleukin-4 (IL-4) leads to polarisation into pro-inflammatory or anti-inflammatory subtypes, which produce key enzymes such as inducible nitric oxide synthase (iNOS) and arginase 1 (ARG1), respectively, and in this way determine host responses to infection. Importantly, L-arginine … huntington\u0027s disease x linked
Bacteria-triggered tumor-specific thrombosis to enable …
Web27 Feb 2024 · The mice treated with ΔppGpp S. Gallinarum expressing the immunotoxin survived 10–15 days longer than the mice treated with PBS or ΔppGpp S. Gallinarum alone (Figure 4C,F). Taken together, the results suggest that TP expressed from the constitutive rrnB P1 promoter in ΔppGpp S. Gallinarum effectively suppressed tumor growth without … WebOther articles where Salmonella typhimurium is discussed: salmonellosis: Gastroenteritis is caused primarily by S. typhimurium and S. enteritidis; it occurs following ingestion of the bacteria on or in food, in water, or on … Web4 Jan 2010 · Here, we engineered attenuated S. typhimurium defective in guanosine 5′-diphosphate-3′-diphosphate (ppGpp) synthesis (ΔppGpp strain) to express both the … huntington\\u0027s drugs