To prevent cisplatin nephropathy
WebDec 13, 2024 · DS-5272 co-treatment reduced both cisplatin-induced cell death and NFκB transcriptional activity. Collectively, these findings suggest that DS-5272 can ameliorate cisplatin nephrotoxicity via NFκB signal inhibition. Abbreviations LDH
To prevent cisplatin nephropathy
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WebOct 19, 2024 · The best way to prevent or delay diabetic nephropathy is by maintaining a … WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose …
WebCisplatin-induced acute kidney injury is a serious problem in cancer patients during treatment of solid tumors. Currently, there are no therapies … WebBackground A strategy for preventing cisplatin nephrotoxicity due to enhanced oxidative stress and inflammatory response is highly desirable. Thioredoxin-1 (Trx), an endogenous redox-active protein,
WebJul 1, 2013 · Recent studies have identified a dual role for MΦ in several murine models of kidney disease. In this review, we discuss the pathogenic and protective roles of the various MΦ subsets in experimental and human kidney diseases and summarize current progress toward the therapeutic use of MΦ in kidney diseases. ... Cisplatin is widely used to ... WebNov 11, 2024 · Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related nephropathy. In this study, we evaluated the correlation between mitophagy and the protective effect of the Nrf2 activator farrerol on cisplatin-induced CKD by using C57BL/6 wild-type and Nrf2 knockout mice.
WebFeb 1, 2024 · Cisplatin injection is used to treat advanced cancer of the bladder, ovaries, or …
WebAcute and chronic kidney disease encompasses a complex set of diseases that can both lead to, and result from, cancer. In particular, kidney disease can arise from the use of chemotherapeutic agents. ... in-vivo studies suggest that teneligliptin, a DPP-4 inhibitor, might prevent cisplatin-induced nephrotoxicity and improve kidney function in ... i deleted my phone icon on my iphoneWebApr 24, 2024 · The findings contained within this systematic review show that (a) hydration is essential for all patients to prevent cisplatin‐induced nephrotoxicity, (b) short‐duration, low‐volume, outpatient hydration regimens appear to be safe and feasible, even in patients receiving intermediate‐ to high‐dose cisplatin, (c) magnesium supplementation (8–16 … i deleted my network adapter windows 10WebRisk of drug nephrotoxicity is increased in the patient with AKI or chronic kidney disease (CKD). Thus, the patient who is on diuretic therapy or has vomiting or diarrhea that results in true volume depletion is vulnerable to toxic drug effects on the kidney. ... Some strategies to prevent cisplatin nephrotoxicity include intravenous volume ... i deleted my recycle binWebApr 14, 2024 · Africa, particularly sub-Sharan Africa (SSA), faces major challenges in respect to chronic kidney disease (CKD). There is a rising prevalence due to the combined effects of hypertension, diabetes, and human immunodeficiency virus (HIV) (and the interaction between them) and the effect of apolipoprotein L1 (APOL1) variants on the susceptibility … i deleted my phone icon on my iphone 12WebAug 22, 2015 · The standard approach for prevention of CIN is the administration of lower … i deleted my sd card readerWebOct 14, 2024 · To prevent both the short- and long-term effects of cisplatin, researchers … i deleted my wifi driver windows 10WebNov 1, 2024 · Even after a single-dose injection of cisplatin (50–100 mg/m 2), approximately one-third of the patients develop acute kidney injury (AKI) characterized by a rapid decline in renal function. Patients with AKI have a 50% mortality rate, and surviving AKI patients are likely to develop chronic kidney disease in months to years [2]. i deleted my yahoo account and want it back